Cell BiologybioRxiv
The oncogenic transcription factor FUS-CHOP can undergo nuclear liquid-liquid phase separation
I. Owen, D. Yee, H. Wyne…·F. Shewmaker
This study shows the FUS-CHOP fusion protein undergoes nuclear liquid-liquid phase separation, forming condensates at super enhancer sites, suggesting a novel oncogenic mechanism in myxoid liposarcoma.
DOI 10.1242/jcs.258578