CXCL4-induced PBMCs Modulate Vascular Extracellular Matrix through Wnt5a-dependent Release of Calcific Extracellular Vesicles and Matrix Metalloproteinase-7
J. B. Krohn, F. Sicklinger, A. Spieler, S. Dihlmann, C. A. Gleissner, H. A. Katus, N. Frey, F. Leuschner
This study identifies a novel mechanism by which CXCL4-induced monocytes release calcific extracellular vesicles and MMP7 to modulate vascular extracellular matrix through Wnt5a-CaMKII signaling.
bioRxiv · May 15, 2023 · PreprintImmunology