Author

F. Leuschner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell-cell communication· 3 Research Focus:differential expression· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Organism:mouse· 2 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

F. Sicklinger· 2 shared N. Frey· 2 shared A. Debes· 1 shared A. L. Bailey· 1 shared A. L. Bredemeyer· 1 shared A. M. Zeiher· 1 shared A. P. Nair· 1 shared A. S. Rali· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersImmunology

F. Sicklinger

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

CXCL4-induced PBMCs Modulate Vascular Extracellular Matrix through Wnt5a-dependent Release of Calcific Extracellular Vesicles and Matrix Metalloproteinase-7

J. B. Krohn, F. Sicklinger, A. Spieler, S. Dihlmann, C. A. Gleissner, H. A. Katus, N. Frey, F. Leuschner

This study identifies a novel mechanism by which CXCL4-induced monocytes release calcific extracellular vesicles and MMP7 to modulate vascular extracellular matrix through Wnt5a-CaMKII signaling.

bioRxiv · May 15, 2023 · PreprintImmunology

Single-cell transcriptomics reveal distinctive patterns of fibroblast activation in murine heart failure with preserved ejection fraction

J. D. Lanzer, L. M. Wienecke, R. O. Ramirez-Flores, M. M. Zylla, N. Hartmann, F. Sicklinger, J. H. Schultz, N. Frey, J. Saez-Rodriguez, F. Leuschner

This study uses single-cell RNAseq to identify distinct fibroblast and macrophage activation patterns in murine HFpEF, revealing disease-specific transcriptional signatures and a potential biomarker.

bioRxiv · May 9, 2023Cell Biology

DNMT3A clonal hematopoiesis-driver mutations induce cardiac fibrosis by paracrine activation of fibroblasts

M. Shumliakivska, G. Luxan, I. Hemmerling, W. T. Abplanalp, X. Li, M. Scheller, C. Muller-Tidow, F. Leuschner, B. Schuhmacher, A. Debes, S.-F. Glaser, M. Muhly Reinholz, K. Kirschbaum, J. Hoffmann, E. Nagel, , S. Dimmeler

This study shows that DNMT3A mutations in hematopoietic cells drive cardiac fibrosis by activating fibroblasts through paracrine signaling, contributing to heart failure progression.

bioRxiv · Jan 7, 2023Physiology

SARS-CoV-2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis

A. L. Bailey, O. Dmytrenko, L. Greenberg, A. L. Bredemeyer, P. Ma, J. Liu, V. Penna, L. Lai, E. S. Winkler, S. Sviben, E. Brooks, A. P. Nair, K. A. Heck, A. S. Rali, L. Simpson, , K. J. Lavine

This study shows SARS-CoV-2 infects human engineered heart tissues, causing myocarditis-like features, and identifies ACE2 and proteases as entry factors.

bioRxiv · Nov 4, 2020Immunology