N. Frey

Tryptophan wasting and disease activity as a systems phenomenon in inflammation - an analysis across 13 chronic inflammatory diseases.

This study examines tryptophan wasting across 13 chronic inflammatory diseases, finding reduced serum tryptophan levels and increased kynurenine pathway activity linked to disease activity.

CXCL4-induced PBMCs Modulate Vascular Extracellular Matrix through Wnt5a-dependent Release of Calcific Extracellular Vesicles and Matrix Metalloproteinase-7

This study identifies a novel mechanism by which CXCL4-induced monocytes release calcific extracellular vesicles and MMP7 to modulate vascular extracellular matrix through Wnt5a-CaMKII signaling.

Single-cell transcriptomics reveal distinctive patterns of fibroblast activation in murine heart failure with preserved ejection fraction

This study uses single-cell RNAseq to identify distinct fibroblast and macrophage activation patterns in murine HFpEF, revealing disease-specific transcriptional signatures and a potential biomarker.

Amino acid auxotrophies in human gut bacteria are linked to higher microbiome diversity and long-term stability

This study links amino acid auxotrophies in human gut bacteria to increased microbiome diversity and long-term stability through a combined metabolomic, metagenomic, and metabolic modeling approach.

S100A1ct: a synthetic peptide derived from human S100A1 protein improves cardiac contractile performance and survival in pre-clinical heart failure models

This paper develops a synthetic peptide S100A1ct that improves cardiac function and survival in heart failure models by enhancing Ca2+ cycling and targeting SERCA2a and RyR2.

Cardiac-targeted rAAV5-S100A1 gene therapy protects against adverse remodeling and contractile dysfunction in post-ischemic hearts

This study demonstrates that cardiac-targeted rAAV5-S100A1 gene therapy reduces adverse remodeling and improves contractile function in post-ischemic hearts in pigs and mice.

Loss of Rnf31 and Vps4b sensitizes pancreatic cancer to T cell-mediated killing

This study identifies Rnf31 and Vps4b as factors enabling pancreatic cancer to evade T cell killing, showing their inactivation increases T cell-mediated tumor cell death.