Cell BiologybioRxivPreprint
Intracellular BAPTA directly inhibits PFKFB3, thereby impeding mTORC1-driven Mcl-1 translation and killing Mcl-1-addicted cancer cells
F. Sneyers, M. Kerkhofs, K. Welkenhuyzen…·G. Bultynck
This paper shows that BAPTAi inhibits PFKFB3, reducing mTORC1-driven Mcl-1 translation and killing Mcl-1-dependent cancer cells, independent of Ca2+ signaling.
DOI 10.1101/2022.10.31.512457