Innate immune response to SARS-1 CoV-2 infection contributes to neuronal damage in human iPSC-derived peripheral neurons
V. Passos, L. M. Henkel, J. Wang, F. J. Zapatero-Belinchon, R. Moeller, G. Sun, I. Waltl, B. Ritter, K. A. Kropp, S. Zhu, M. Deleidi, U. Kalinke, G. Hoeglinger, G. Gerold, F. Wegner, A. Viejo-Borbolla
This study infects human iPSC-derived CNS and PNS neurons with SARS-CoV-2 and finds that PNS neurons experience more severe neurodegeneration linked to innate immune activation.
bioRxiv · Nov 18, 2022Microbiology