Author

R. Moeller

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Bioengineering· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Approach:statistical model· 2 Assay:CRISPR screen· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

B. R. tenOever· 2 shared B. tenOever· 2 shared D. A. Hoagland· 2 shared A. Lachmann· 1 shared A. Ma'ayan· 1 shared A. Murphy· 1 shared A. Viejo-Borbolla· 1 shared B. Javidfar· 1 shared

Activity by Year

2020-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersMicrobiology

B. R. tenOever

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Innate immune response to SARS-1 CoV-2 infection contributes to neuronal damage in human iPSC-derived peripheral neurons

V. Passos, L. M. Henkel, J. Wang, F. J. Zapatero-Belinchon, R. Moeller, G. Sun, I. Waltl, B. Ritter, K. A. Kropp, S. Zhu, M. Deleidi, U. Kalinke, G. Hoeglinger, G. Gerold, F. Wegner, A. Viejo-Borbolla

This study infects human iPSC-derived CNS and PNS neurons with SARS-CoV-2 and finds that PNS neurons experience more severe neurodegeneration linked to innate immune activation.

bioRxiv · Nov 18, 2022Microbiology

Common genetic variation in humans impacts in vitro susceptibility to SARS-CoV-2 infection

K. Dobrindt, D. A. Hoagland, C. Seah, B. Kassim, C. P. O'Shea, M. Iskhakova, M. Fernando, P. M. Deans, S. K. Powell, B. Javidfar, A. Murphy, C. Peter, R. Moeller, M. Fernandez Garcia, M. Kimura, , K. J. Brennand

This study shows that a common genetic variant in the FURIN gene affects SARS-CoV-2 infection in vitro, suggesting genetic factors contribute to clinical variability in COVID-19.

bioRxiv · Sep 20, 2020Cell Biology

Modulating the transcriptional landscape of SARS-CoV-2 as an effective method for developing antiviral compounds

D. A. Hoagland, D. J. B. Clarke, R. Moeller, Y. Han, L. Yang, M. L. Wojciechowicz, A. Lachmann, K. Y. Oguntuyo, C. Stevens, B. Lee, S. Chen, A. Ma'ayan, B. R. tenOever

This study identifies antiviral compounds that reduce SARS-CoV-2 viral load by counteracting the virus-induced transcriptional landscape, without affecting viral entry or host antiviral response.

bioRxiv · Jul 12, 2020 · PreprintMicrobiology

SARS-CoV-2 launches a unique transcriptional signature from in vitro, ex vivo, and in vivo systems

D. Blanco-Melo, B. Nilsson-Payant, W.-C. Liu, R. Moeller, M. Panis, D. Sachs, R. Albrecht, B. R. tenOever

This study characterizes the host transcriptional response to SARS-CoV-2 and other respiratory viruses in multiple models, finding a unique muted response lacking certain cytokine and chemokine induction.

bioRxiv · Mar 24, 2020Microbiology

Engineering an RNA-based tissue-specific platform for genetic editing through use of a miRNA-enabled Cas12a

R. Moeller, K. Oishi, B. tenOever

This paper develops an RNA-based CRISPR-Cas12a system that enables tissue-specific genetic editing with reduced immunogenicity through miRNA-dependent crRNA maturation and self-inactivation.

bioRxiv · Mar 4, 2020 · PreprintBioengineering