G. Sun

Off-the-shelf image analysis models outperform human visual assessment in identifying genes controlling seed color variation in sorghum

The paper uses image analysis models to quantify seed color in sorghum, finding they outperform human assessment and identify more genomic signals linked to seed color genes.

Non-Invasive Quality Control of Organoid Cultures Using Mesofluidic CSTR Bioreactors and High-Content Imaging

This paper develops a mesofluidic bioreactor platform with high-content imaging for non-invasive quality control of brain organoids, improving their development and reducing cell death.

Down regulation of Engase in Caenorhabditis elegans may improve its stresses adaptivity

This study shows that downregulating CeEngase in C. elegans enhances its adaptability to heat and osmotic stress.

Repression of varicella zoster virus gene expression during quiescent infection in the absence of detectable histone deposition

This study investigates VZV gene repression in neuronal cells, finding that histone deposition is absent at quiescent viral genomes.

PFS alleviates bone destruction in collagen-induced arthritis mice associated with macrophage polarization

This study shows that PFS reduces bone destruction and shifts macrophage polarization from M1 to M2 in arthritis mice, suggesting its potential as an RA treatment.

A nanobody-enzyme fusion protein targeting PD-L1 and sialic acid exerts anti-tumor effects by affecting tumor associated macrophages

This study develops a nanobody-enzyme fusion protein targeting PD-L1 and sialic acid, showing anti-tumor effects by modulating tumor-associated macrophages.

A Germinal Center Checkpoint of AIRE in B Cells Limits Antibody Diversification

This study identifies AIRE as a checkpoint in germinal center B cells that limits antibody diversification by inhibiting AID function, leading to autoimmunity and impaired immune responses.

Mapping the tRNA Modification Landscape of Bartonella henselae Houston I and Bartonella quintana Toulouse

The paper maps tRNA modifications and their synthesis genes in two Bartonella species, identifying gene reductions linked to reductive evolution.

Alternate routes to mnm5s2U synthesis in Gram-positive bacteria

This paper identifies a novel pathway for mnm5s2U synthesis in Gram-positive bacteria, revealing alternative biosynthetic mechanisms involving the MnmL enzyme.

Data driven discovery and quantification of hyperspectral leaf reflectance phenotypes across a maize diversity panel

This study uses data-driven methods to analyze hyperspectral leaf reflectance data from maize plants, identifying genetic markers correlated with reflectance patterns and chlorophyll content.

Queuosine Salvage in Bartonella henselae Houston 1: A Unique Evolutionary Path

This study identifies a unique evolutionary pathway in Bartonella henselae for queuosine salvage, showing it can use both preQ1 and q, unlike other pathogens.

Haptenic adducts of beta-lactam antibiotics elicit antibody responses with narrow clonality and specificity

This study investigates how penicillin G forms immunogenic adducts on proteins and elicits specific antibody responses in mice, revealing clonal dominance and limited cross-reactivity with other beta-lactam antibiotics.

Population level gene expression can repeatedly link genes to functions in maize

This study uses transcriptome-wide association studies in maize to identify flowering time genes, finding TWAS detects more genes than GWAS and links gene expression to function across tissues and environments.

Identification and characterization of a beta-1,4 Galactosidase from Elizabethkingia meningoseptica and its application on living cell surface

This study identifies and characterizes a beta-1,4 galactosidase from Elizabethkingia meningoseptica that can remove galactose from living cell surfaces, named geGalaseI.

Engineered display of ganglioside-sugars on protein elicits a clonally and structurally constrained B cell response

This paper shows that displaying GM3g glycans on proteins using specific chemical linkers elicits strong, germline-encoded B cell responses that do not undergo affinity maturation.

MYSM1 co-activates ERα action via histone and non-histone deubiquitination to confer antiestrogen resistance in breast cancer

This study identifies MYSM1 as an ER co-activator that promotes antiestrogen resistance in breast cancer through histone and non-histone deubiquitination.

Innate immune response to SARS-1 CoV-2 infection contributes to neuronal damage in human iPSC-derived peripheral neurons

This study infects human iPSC-derived CNS and PNS neurons with SARS-CoV-2 and finds that PNS neurons experience more severe neurodegeneration linked to innate immune activation.

Parallel use of pluripotent human stem cell lung and heart models provide new insights for treatment of SARS-CoV-2

The paper uses human pluripotent stem cell-derived lung and heart models to identify antiviral compounds with distinct profiles, highlighting the need for multi-organ testing in SARS-CoV-2 treatment.

Distinct roles of Nrf1 and Nrf2 in monitoring the reductive stress response to dithiothreitol (DTT)

This paper investigates the distinct roles of Nrf1 and Nrf2 in the reductive stress response to DTT, showing differential regulation of redox and ER stress defense genes.

A full spectrum PNGase activity analysis of R328 mutations on NGLY1

This study evaluates the impact of R328 mutations on NGLY1 activity using an in vitro assay, identifying dysfunctional, similar, and decreased activity mutations.

Association Mapping Across a Multitude of Traits Collected in Diverse Environments Identifies Pleiotropic Loci in Maize.

This study identifies pleiotropic loci in maize by analyzing trait associations across diverse environments using high-density genetic markers and resampling-based genome-wide association tests.

An enzyme-based system for the extraction of small extracellular vesicles from plants

This study develops an enzyme-based method to extract plant extracellular vesicles, showing higher yield and therapeutic potential compared to traditional methods.

An iTSC-derived placental model of SARS-CoV-2 infection unveils ACE2-dependent susceptibility in syncytiotrophoblasts

This study develops an in vitro model of SARS-CoV-2 infection in placental cells using iTSCs, showing that syncytiotrophoblasts are infected and that ACE2 inhibition prevents infection and restores function.

The Wolbachia CinB Nuclease is Sufficient for Induction of Cytoplasmic Incompatibility

This paper shows that the Wolbachia CinB nuclease alone can induce cytoplasmic incompatibility in Drosophila males, with rescue by cognate CifA in females.

The genome of stress tolerant crop wild relativePaspalum vaginatum leads to increased biomassproductivity in the crop Zea mays

This study sequenced Paspalum vaginatum, a stress-tolerant wild relative of maize, and found that inducing trehalose accumulation in maize increases biomass through autophagy.

WDR82-binding long non-coding RNA lncEry controls mouse erythroid differentiation and maturation

The paper identifies lncEry, a long non-coding RNA that regulates mouse erythroid differentiation and maturation by interacting with WDR82 to control Klf1 and globin gene transcription.

Single Cell Raman-Deuterium Isotope Probing for Drug Resistance of Elizabethkingia spp.

This study uses single cell Raman-DIP to rapidly determine antimicrobial susceptibility of Elizabethkingia spp. and confirms minocycline and levofloxacin as first-line treatments.

Injectable Progranulin-derivative Atsttrin loaded Protein Engineered Gels for Post Traumatic Osteoarthritis

This paper develops a protein-based gel that delivers Atsttrin to prevent post-traumatic osteoarthritis in a rabbit model.

Mechanistic insights into dideoxygenation in gentamicin biosynthesis

The paper elucidates the dideoxygenation mechanism in gentamicin biosynthesis, showing how intermediates JI-20A and JI-20B are converted to gentamicin C complex through phosphorylation and PLP-dependent enzymatic reactions.

Quantitative resistance loci to southern rust mapped in a temperate maize diversity panel

The paper maps quantitative resistance loci to southern rust in a temperate maize diversity panel using genome-wide association studies and transcriptome-wide association studies.