Faulty Metabolism: A Potential Instigator of an Aggressive Phenotype in Cdk5-dependent Medullary Thyroid Carcinoma
P. Gupta, B. Herring, N. Kumar, R. Telange, S. Garcia-Buntley, T. Caceres, S. Colantonio, F. Williams, P. Kurup, A. M. Carter, D. Lin, H. Chen, B. Rose, R. Jaskula-Sztul, M. S. Mukhtar, , J. A. Bibb
This study establishes mouse models of Cdk5-driven Medullary Thyroid Carcinoma (MTC) that recapitulate human tumor aggressiveness and identifies metabolic pathway perturbations as critical for aggressive growth.
bioRxiv · Jun 13, 2023 · PreprintCancer Biology