P. Gupta

Phylogenetically distant enzymes localized in cytosol and plastids drive citral biosynthesis in lemongrass

This study identifies two phylogenetically distant enzymes, CfADH1 and CfAKR2b, localized in cytosol and plastids, that drive citral biosynthesis in lemongrass.

Intra-DNA k-mer Conservation Patterns Encode Evolutionary Selection of Variants

The paper introduces kGain, a metric quantifying k-mer frequency shifts due to mutations, and shows it predicts adaptive potential across species and experimental systems.

Kingdom-specific lipid unsaturation shapes up sequence evolution in membrane arm subunits of eukaryotic respiratory complexes

The paper investigates how lipid-protein interactions constrain sequence evolution in membrane subunits of eukaryotic respiratory complexes, finding that lipid-exposed surfaces show non-PPI disease mutations and kingdom-specific lipid unsaturation affects stability.

An Autonomous Implantable Device for the Prevention of Death from Opioid Overdose

The paper introduces an implantable device that autonomously detects and treats opioid overdose, improving survival rates by delivering naloxone and alerting first responders.

A tomato ethylene-insensitive mutant displays altered growth and higher β-carotene levels in fruit

Analysis of root volatiles and functional characterization of a root-specific germacrene A synthase in Artemisia pallens

The paper identifies and functionally characterizes a root-specific terpene synthase in Artemisia pallens that produces major root volatiles.

Mechanical imbalance between normal and transformed cells drives epithelial homeostasis through cell competition

This study identifies a mechanical imbalance between normal and transformed cells in epithelial tissue, showing that transformed cells are more compressible due to weakened adhesions, driving cell competition and homeostasis.

A Parasite Odyssey: An RNA virus concealed in Toxoplasma gondii

The paper identifies a novel narnavirus, Apocryptovirus odysseus, potentially infecting Toxoplasma gondii, and suggests it may act as a pro-inflammatory factor in host cells.

Transcriptional modulation during photomorphogenesis in rice seedlings

The paper investigates light-induced transcript splicing and gene expression changes in rice seedlings using RNA-Seq, identifying differentially expressed genes and alternative splicing events.

Double Imprinted Nanoparticles for Sequential Membrane-to-Nuclear Drug Delivery

This study develops double imprinted nanoparticles for targeted drug delivery to breast cancer cells, showing enhanced toxicity in ER-positive cells and reduced side effects.

Faulty Metabolism: A Potential Instigator of an Aggressive Phenotype in Cdk5-dependent Medullary Thyroid Carcinoma

This study establishes mouse models of Cdk5-driven Medullary Thyroid Carcinoma (MTC) that recapitulate human tumor aggressiveness and identifies metabolic pathway perturbations as critical for aggressive growth.

Ythdf2 regulates cardiac remodeling through its m6A-mRNA target transcripts

This study shows that Ythdf2, an m6A reader protein, regulates cardiac function by controlling gene expression through its target transcripts, leading to cardiac remodeling in heart failure models.

Introgression of a dominant phototropin1 mutant superenhances carotenoids and boosts flavor-related volatiles in genome-edited tomato RIN mutants

This study introduces a tomato cultivar with extended shelf life, improved taste, and flavor by combining genome-edited ripening mutants with a phototropin1 mutant.

Multiplexed fluorescence and scatter detection with single cell resolution using on-chip fiber optics for droplet microfluidic applications

The paper introduces OptiDrop, a platform that enables multi-parametric optical sensing of microfluidic droplets with single-cell resolution using on-chip fiber optics.

Trilliumosides A-B, two novel steroidal saponins isolated from Rhizomes of Trillium govanianum as potent anticancer agents targeting apoptosis in A-549 cancer cell line.

This study isolates two novel steroidal saponins from Trillium govanianum rhizomes and demonstrates their potent anticancer activity against A-549 cells through apoptosis induction.

Triggering receptor expressed on myeloid cells 2 (TREM2) regulates phagocytosis in glioblastoma

This study shows TREM2 promotes phagocytosis in gliomas and is not linked to immunosuppression, suggesting TREM2 activation could enhance immunotherapy for brain tumors.

ZEB1-dependent modulation of fibroblast polarization governs inflammation and immune checkpoint blockade sensitivity in colorectal cancer

This study shows that ZEB1 in cancer-associated fibroblasts suppresses anti-tumor immunity and promotes metastasis, and its loss increases immune checkpoint sensitivity.

Novel Peptide Inhibitor of Human Tumor Necrosis Factor-α has Antiarthritic Activity

The paper designs a peptide inhibitor of TNF-α that reduces inflammation and joint damage in arthritis models.

Immune Contexture of Isocitrate Dehydrogenase stratified Human Gliomas

The paper provides a comprehensive analysis of immune contexture in IDH stratified human gliomas using single-cell RNA sequencing and spectral cytometry, identifying TREM2 as a novel immunotherapy target.

A mechanistic insight into Nigella sativa mediated anticancer effect on breast cancer through regulation of various miRNAs: An in vitro & in vivo study

This study investigates the anticancer effects of Nigella sativa volatile oil on breast cancer cells and mice, showing synergistic anti-tumorigenic properties through miRNA regulation and apoptosis induction.

Neuronal Maturation-dependent Nano-Neuro Interaction and Modulation

This study investigates nano-neuro interactions during neural network maturation, finding that nanoparticle density correlates with neuronal maturation stage and results in heterogeneous optical neuromodulation.

Reduced γ-glutamyl hydrolase activity likely contributes to high folate levels in Periyakulam-1 tomato

The paper identifies reduced γ-glutamyl hydrolase activity in PKM-1 tomato as a factor contributing to higher folate levels compared to AV.

Development of an efficient single-cell cloning and expansion strategy for genome edited induced pluripotent stem cells

This paper develops an efficient single-cell cloning and expansion strategy for genome-edited hiPSCs, improving viability and expansion while maintaining pluripotency.

Whole-Genome Profiling of Ethyl Methanesulfonate Mutagenesis in Tomato

This study sequenced mutagenized tomato lines to identify mutations, revealing high mutation density and novel insights into EMS mutagenesis patterns and their impact on metabolic pathways.

Genetic Impairment of Succinate Metabolism Disrupts Bioenergetic Sensing in Adrenal Neuroendocrine Cancer

This paper shows that loss of SDHB in adrenal neuroendocrine cancer disrupts bioenergetic sensing through Cdk5 activation, leading to tumor progression, and that Cdk5 inhibition can reverse this process.

Plausible Mechanistic Insights in Biofilm Eradication Potential of against Candida spp. using In Situ Synthesized Tyrosol Functionalized Chitosan Gold Nanoparticles as a versatile Antifouling Coating on Implant Surfaces

This study evaluates the antifungal and antibiofilm effects of tyrosol functionalized chitosan gold nanoparticles against Candida species and identifies mechanisms of action.

Molecular characterization of carbapenem resistant Klebsiella pneumoniae clinical isolates: Preliminary experience from a tertiary care teaching hospital in the Himalayas

This study uses whole-genome sequencing to characterize carbapenem-resistant Klebsiella pneumoniae isolates from a hospital in Uttarakhand, India, identifying common sequence types, virulence factors, and plasmid replicons.

Phytoene synthase 2 in tomato fruits remains functional and contributes to abscisic acid formation

The paper shows that PSY2 contributes to abscisic acid formation in ripening tomato fruits by maintaining a parallel carotenogenesis pathway when PSY1 is absent.

The Evolutionary History of Small RNAs in the Solanaceae

The paper uses over 255 small RNA datasets to characterize the small RNA landscape across the Solanaceae family, revealing dynamic evolutionary patterns and genus-specific similarities.

miRador: a fast and precise tool for the prediction of plant miRNAs

miRador is a tool for plant miRNA prediction that is as precise as existing tools but significantly faster.