Loss of soluble guanylyl cyclase in platelets contributes to atherosclerotic plaque formation and vascular inflammation
C. Mauersberger, H. B. Sager, J. Wobst, T. A. Dang, L. Lambrecht, S. Koplev, M. Stroth, N. Bettaga, J. Schlossmann, F. Wunder, A. Friebe, J. L. Bjoerkegren, L. Dietz, P. Sandner, O. Soehnlein, , T. Kessler
This study shows that loss of soluble guanylyl cyclase in platelets promotes atherosclerosis by reducing angiopoietin-1 release and increasing leukocyte adhesion, suggesting sGC stimulation as a potential therapy for coronary artery disease.
bioRxiv · Nov 15, 2021Physiology