Author

Fangzhou Bian

University of Southern California

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Cell Biology· 1 Developmental Biology· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Hong Colleen Feng· 3 shared Jingyu HeiD· 3 shared Zhaoyang LiuiD· 3 shared Arijita SarkariD· 2 shared Denis A. EvseenkoiD· 2 shared Hanhan Tang· 2 shared Jade TasseyiD· 2 shared Jenny MagallanesiD· 2 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersDevelopmental Biology

Hong Colleen Feng

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Distinct Biological and Biomechanical Features in TMJ and Knee Cartilages

Jingyu He, Hong Colleen Feng, Junxi Guo, Julia Raulino Lima, Mohammadreza Vatankhah, Fangzhou Bian, Holly Katherine Johnson, Courtney Leong, Laura Voskanyan, Jantzen Blaine Ebreo, Parth Kotak, Clark Gt, Anette Vistoso Monreal, Amy Elizabeth Merrill, Jian-Fu Chen, , Zhaoyang Liu

This study compares the biological and biomechanical features of mandibular condylar cartilage and articular cartilage in mice, revealing distinct structural and functional differences.

bioRxiv · Feb 23, 2026 · PreprintDevelopmental Biology

Variants in the SOX9 transactivation middle domain induce axial skeleton dysplasia and scoliosis

Lianlei Wang, Zhaoyang Liu, Sen Zhao, Kexin Xu, Valeria Aceves, Cheng Qiu, Hong Colleen Feng, Fangzhou Bian, Jingyu He, Christina J. Song, Benjamin Troutwine, Lian Liu, Samuel Ma, Yuchen Niu, Shengru Wang, , Jiashen Shao

The paper identifies a novel SOX9 variant in the TAM domain linked to axial skeletal dysplasia and scoliosis, showing reduced protein stability and recapitulating human phenotypes in mice.

Proceedings of the National Academy of Sciences · Jan 24, 2025Peer-reviewedGenetic & Genomic Medicine

Inactivation of a non-canonical gp130 signaling arm attenuates chronic systemic inflammation and multimorbidity induced by a high-fat diet.

Y.-J. Lee, Jade Tassey, Arijita Sarkar, Jonathan N. Levi, Siyoung Lee, Nancy Q. Liu, Andrew C. Drake, Falisha Nguyen, Jenny Magallanes, Una Stevic, Jinxiu Lu, Dawei Ge, Hanhan Tang, Tadiwanashe Mkaratigwa, Jichen Yang, , Denis A. Evseenko

This study shows that inhibiting a non-canonical gp130 signaling pathway reduces chronic inflammation and multimorbidity in a high-fat diet model.

Scientific Reports · Dec 28, 2024Peer-reviewedCell Biology

Spatial Transcriptomics Reveals the Requirement of ADGRG6 in Maintaining Chondrocyte Homeostasis in Mouse Growth Plates

Fangzhou Bian, Victoria L. Hansen, Hong Colleen Feng, Jingyu He, Y Chen, Kaining Feng, Brenda Ebrahimi, Ryan S. Gray, Yang Chai, Chia‐Lung Wu, Zhaoyang Liu

This study shows that ADGRG6 is essential for postnatal growth plate homeostasis in mice, affecting chondrocyte survival, proliferation, and differentiation.

Journal of Bone and Mineral Research · Sep 5, 2024Peer-reviewedMolecular Biology

Genome-wide DNA methylation and multi-omics study of human chondrocyte ontogeny and an epigenetic clock analysis of adult chondrocytes

Arijita Sarkar, Nancy Q. Liu, Jenny Magallanes, Jade Tassey, Siyoung Lee, Ruzanna Shkhyan, Young‐Joo Lee, Jinxiu Lu, Yuxin Ouyang, Hanhan Tang, Fangzhou Bian, Litao Tao, Neil Segil, Jason Ernst, Karen M. Lyons, , Denis A. Evseenko

This study examines DNA methylation changes in human chondrocytes across ontogeny and develops an epigenetic clock showing STAT3 agonist reduces epigenetic age in aged chondrocytes.

Aging Cell · Jan 13, 2023Peer-reviewedMolecular Biology