Y Chen

CSGDA: A Cell State-Guided Graph Domain Adaptation Network for Single-Cell Drug Response Prediction

CSGDA predicts drug responses across biological heterogeneities by addressing distribution shifts using a cell state-guided graph domain adaptation framework.

Airway Diameter-Matched Injury Improves Severity and Reproducibility of Experimental Rabbit Tracheal Stenosis

This study shows that matching injury tool size to measured airway diameter in rabbits improves tracheal stenosis severity and reproducibility, while body weight is not a reliable surrogate for airway size.

Benzoxaboroles are structurally unique binders of eukaryotic translation initiation factor 4E

The paper identifies benzoxaboroles as selective binders of eIF4E, revealing stereoselective interactions and structural insights into their binding mechanism.

The BELL-type homeobox transcription factor RLC3/OsBLH4 controls leaf rolling and drought tolerance via KNOX-BELL-lignin regulatory network in rice

Spatial Transcriptomics Reveals the Requirement of ADGRG6 in Maintaining Chondrocyte Homeostasis in Mouse Growth Plates

This study shows that ADGRG6 is essential for postnatal growth plate homeostasis in mice, affecting chondrocyte survival, proliferation, and differentiation.

Antigen presentation by discrete class I molecules on brain endothelium dynamically regulates T-cell mediated neuropathology in experimental cerebral malaria

This study shows that specific MHC class I molecules on brain endothelium regulate CD8 T cell activity and neuropathology in experimental cerebral malaria.