ImmunologybioRxivPreprint
Cytotoxic CD4+ exTregs expressing KLRG1 retain immunosuppressive function in cancer
Collin Jugler, Kade R Copple, Jessica C Hill…·Casey R Ager
This study identifies KLRG1+ cytotoxic CD4+ T cells in tumors that retain immunosuppressive function, derived from Tregs, and suggests KLRG1-targeted depletion may be more effective than blockade in cancer therapy.