Fei Liu

Classifying tumors from broad category to hierarchical molecular subtype: an interpretable hierarchical framework for precision oncology

This paper introduces HHRM, a hierarchical model for tumor subtype classification, achieving high accuracy in pan-cancer and breast cancer subtyping with interpretable biomarker identification.

A multi-tissue epigenomic atlas links the sheep non-coding genome to domestication and complex traits

SheepEpimap combines 516 histone CUT&Tag, ATAC-seq and RNA-seq datasets from 43 sheep tissues to annotate 2.93 million cis-regulatory elements and 145,407 allele-specific variants for trait interpretation.

scRGCL: Neighbor-Aware Graph Contrastive Learning for Robust Single-Cell Clustering

scRGCL improves single-cell clustering by integrating contrastive learning with cluster-level guidance, achieving better performance on multiple datasets.

Microglia Piezo1 aggravates cerebral ischemia and reperfusion injury by chemotactic recruitment of T lymphocytes

This study shows that microglia Piezo1 deficiency reduces T lymphocyte infiltration and inflammation after cerebral ischemia reperfusion injury.

Cell-type specific inference from bulk RNA-sequencing data by integrating single cell reference profiles via EPIC-unmix

EPIC-unmix improves cell-type specific analysis from bulk RNA-seq by integrating single-cell reference profiles, identifying novel genes and eQTLs in Alzheimer's disease.

Novel symbionts reveal amoebae as significant hosts for environmental chlamydiae

This study identifies novel environmental chlamydiae in wild amoebae, revealing their host specificity and expanding the known chlamydial host range.