Pharmacology & ToxicologyArchives of ToxicologyPeer-reviewed
Identification of Functional Genetic Components Modulating Toxicity Response to PFOS using Genome-wide CRISPR Screens in HepG2/C3A cells
Chanhee Kim, Abderrahmane Tagmount, Zhaohan Zhu…·Chris D. Vulpe
This study identifies 340 genes modulating PFOS-induced cytotoxicity in liver cells using CRISPR screens and validates two genes, SLC6A9 and CPSF2, with functional and molecular evidence.