Author

Francis Sprouse

Indiana University Indianapolis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Hanghang WangiD· 2 shared Mark J. HenkemeyeriD· 2 shared Amandine C. TaniD· 1 shared Amav Khambete· 1 shared Angus J.M. CameroniD· 1 shared Cerian L. BoltoniD· 1 shared Edward P. CarteriD· 1 shared Ernest M. Kameni· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

Hanghang WangORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Ephrin inhibition disrupts stromal-cancer crosstalk and reduces metastasis in pancreatic cancer

Cerian L. Bolton, Rhianna O’Sullivan, Guillem Fuertes, Francis Sprouse, Hanghang Wang, Shinelle Menezes, Amandine C. Tan, Sabrina Simoncelli, Angus J.M. Cameron, John F. Marshall, Mark J. Henkemeyer, Edward P. Carter, Richard Philip Grose

This study shows that inhibiting Ephrin signaling disrupts stromal-cancer interactions and reduces metastasis in pancreatic cancer using mouse models.

bioRxiv · Dec 13, 2025 · PreprintCancer Biology

Diet-induced MASH liver fibrosis promoted by EphB2 can be targeted by small molecule tetramerization inhibitors

Masaaki Yoshigi, Séverin Donald Kamdem, Hanghang Wang, Amav Khambete, Francis Sprouse, Ernest M. Kameni, Estelle Atiogue, Sarah Pellizzari, Kimberley Jane Evason, My N. Helms, Michael A. Goodman, Shuang Wang, Jisun So, Hyun Cheol Roh, Sihem Boudina, , Patrice Nsangou Mimche

This study identifies EphB2 as a driver of MASH liver fibrosis and shows that targeting EphB2 with small molecule inhibitors can reduce fibrosis in mouse models.

bioRxiv · Nov 19, 2025 · PreprintPathology