Kimberley Jane Evason

This study identifies a kinase network and DAPK3-driven polarity complex that promotes HCC cell migration and metastasis using a multi-modal profiling approach.

This study shows that mitochondrial cardiolipin deficiency disrupts electron transport chain function, leading to oxidative stress and promoting MASH in mice and humans.

This study shows NRF2 drives liver cell plasticity by co-opting the SWI/SNF complex, and identifies FHD-286 as a therapeutic inhibitor of this process.

This study identifies EFHD1 as a Ca2+-dependent stabilizer of ER-mitochondrial contacts that drives liver injury in MASH by promoting mitochondrial fragmentation and antiviral stress responses.

This study identifies YAP's role in disrupting bile acid homeostasis to drive cachexia in zebrafish, showing that promoting bile acid excretion can alleviate the syndrome.

This study identifies miR-21 as a dysregulated microRNA in MASH-HCC, showing it promotes lipid metabolic changes that contribute to hepatocarcinogenesis in zebrafish models.

This study identifies EphB2 as a driver of MASH liver fibrosis and shows that targeting EphB2 with small molecule inhibitors can reduce fibrosis in mouse models.

This study investigates the role of podxl in zebrafish liver development and finds that its loss leads to reduced HSC numbers, with compensation through upregulation of extracellular matrix genes.

This study identifies a redox-sensitive cysteine residue in Oct4 that regulates reprogramming and differentiation by affecting DNA binding and ubiquitylation.

This study identifies a missense mutation in the furinb gene in zebrafish that causes hepatic cysts by disrupting ER homeostasis and mTOR signaling during liver development.