Sihem Boudina

This study identifies PERM1 as a downstream target of PRDM16 and shows that Perm1 gene therapy improves cardiomyopathy in Prdm16 knockout mice through mitochondrial and sarcomere preservation.

This study identifies EFHD1 as a Ca2+-dependent stabilizer of ER-mitochondrial contacts that drives liver injury in MASH by promoting mitochondrial fragmentation and antiviral stress responses.

This study identifies EphB2 as a driver of MASH liver fibrosis and shows that targeting EphB2 with small molecule inhibitors can reduce fibrosis in mouse models.

This study shows that N-acetylcarnosine treatment improves survival and delays age-related decline in multiple organ systems in female mice.

The paper develops a fluorogenic assay to measure chaperone-mediated autophagy (CMA) activity in cells and tissues by using a KFERQ-AMC substrate and quantifying fluorescence release.