NeurosciencebioRxivPreprint
Conformational dynamics of Tau in the cell quantified by an intramolecular FRET biosensor in physiological and pathological context
C Di Primio, V Quercioli, G Siano…·A Cattaneo
This paper develops a conformational-sensitive Tau biosensor to study Tau's 3D structure and aggregation in living cells under physiological and pathological conditions, revealing loop-like MT-bound Tau and relaxed soluble Tau.