Evolutionary BiologybioRxiv
Mutagenesis Mapping of RNA Structures within the Foot-and-Mouth Disease Virus Genome Reveals Functional Elements Localised in the Polymerase (3Dpol) Encoding Region.
L. Lasecka-Dykes, F. Tulloch, P. Simmonds…·M. D. Ryan
The paper identifies three critical RNA structures in the FMDV genome essential for replicon replication, while 42 others are non-essential, suggesting potential targets for vaccine development.
DOI 10.1128/msphere.00015-21