Development and utility of a PAK1-selective degrader
H.-Y. Chow, S. Karchugina, B. J. Groendyke, S. Toenjes, J. Hatcher, K. A. Donovan, E. S. Fischer, G. Abalakov, B. Faezov, R. L. Dunbrack, N. S. Gray, J. Chernoff
This study develops a PAK1-selective degrader, BJG-05-039, which shows enhanced anti-proliferative effects compared to the parent inhibitor NVS-PAK1-1 in PAK1-dependent cell lines.
bioRxiv · May 12, 2022Cancer Biology