Author

R. L. Dunbrack

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biochemistry· 1 Bioengineering· 1 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Assay:protein structure· 3 Approach:statistical model· 3 Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Organism:human· 1

Frequent Co-Authors

B. Faezov· 2 shared J. Adolf-Bryfogle· 2 shared M. I. Parker· 2 shared Q. Xu· 2 shared A. Kurimchak· 1 shared A. Leaver-Fay· 1 shared A. Mihai· 1 shared A. N. Kettenbach· 1 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersImmunology

B. Faezov

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Author profile →

6 papers

Recent·Most cited

E protein control of NKgammadeltaT cell development through both generation and function of the stereotypic Vgamma1Vdelta6.3 TCR

D. L. Wiest, A. Mihai, S.-Y. Lee, S. Shinton, M. I. Parker, A. V. Contreras, B. Zhang, M. Rhodes, R. L. Dunbrack, J. C. Zuniga-Pflucker, M. Ciofani, Y. Zhuang

This study shows that Id3 deficiency affects the development of gamma delta T cell subsets by regulating the generation and function of the Vgamma1Vdelta6.3 TCR.

bioRxiv · Jan 4, 2024 · PreprintImmunology

A penultimate classification of canonical antibody CDR conformations

S. Kelow, B. Faezov, Q. Xu, M. I. Parker, J. Adolf-Bryfogle, R. L. Dunbrack

The paper updates the classification of antibody CDR conformations using improved clustering methods and electron density validation, identifying new clusters and retiring outdated ones.

bioRxiv · Oct 12, 2022 · PreprintImmunology

Development and utility of a PAK1-selective degrader

H.-Y. Chow, S. Karchugina, B. J. Groendyke, S. Toenjes, J. Hatcher, K. A. Donovan, E. S. Fischer, G. Abalakov, B. Faezov, R. L. Dunbrack, N. S. Gray, J. Chernoff

This study develops a PAK1-selective degrader, BJG-05-039, which shows enhanced anti-proliferative effects compared to the parent inhibitor NVS-PAK1-1 in PAK1-dependent cell lines.

bioRxiv · May 12, 2022Cancer Biology

PP2A/B55α substrate recruitment as defined by the retinoblastoma-related protein p107

H. Fowle, Z. Zhao, Q. Xu, X. Wang, M. Adeyemi, F. Feiser, A. Kurimchak, A. N. Kettenbach, R. Page, W. Peti, R. L. Dunbrack, X. Grana

This study identifies a conserved SLiM in p107 that mediates B55 recruitment and dephosphorylation, revealing a general mechanism for PP2A/B55 substrate recognition.

bioRxiv · Mar 2, 2021Biochemistry

RosettaAntibodyDesign (RAbD): A General Framework for Computational Antibody Design

J. Adolf-Bryfogle, O. Kalyuzhniy, M. Kubitz, B. D. Weitzner, X. Hu, Y. Adachi, W. R. Schief, R. L. Dunbrack

This paper introduces RosettaAntibodyDesign (RAbD), a computational framework for antibody design that improves affinity by redesigning CDRs using structural and sequence-based methods.

bioRxiv · Apr 12, 2018Bioengineering

The Rosetta all-atom energy function for macromolecular modeling and design

R. F. Alford, A. Leaver-Fay, J. R. Jeliazkov, M. J. O'Meara, F. P. DiMaio, H. Park, M. V. Shapovalov, P. D. Renfrew, V. K. Mulligan, K. Kappel, J. W. Labonte, M. S. Pacella, R. Bonneau, P. Bradley, R. L. Dunbrack, , J. J. Gray

The paper explains the Rosetta all-atom energy function, its mathematical models, and its application to biomolecular modeling and design, including new capabilities for membrane proteins and other macromolecules.

bioRxiv · Feb 7, 2017Biophysics