Multiparametric domain insertional profiling of Adeno-Associated Virus VP1
M. D. Hoffmann, A. C. Zdechlik, Y. He, D. Nedrud, G. Aslanidi, W. Gordon, D. Schmidt
The paper inserts large protein domains into AAV capsid protein VP1 to identify engineerable hotspots and assess capsid robustness to structural modifications.
bioRxiv · Apr 19, 2023Biochemistry