D. Schmidt

Structure, interaction, and nervous connectivity of beta cell primary cilia

This study reveals the structural and spatial organization of beta cell primary cilia in mouse and human islets, showing their interactions with neighboring cells and nerves, and their role in islet connectivity.

A graded neonatal mouse model of necrotizing enterocolitis demonstrates that mild enterocolitis is sufficient to activate microglia and increase cerebral cytokine expression.

Multiparametric domain insertional profiling of Adeno-Associated Virus VP1

The paper inserts large protein domains into AAV capsid protein VP1 to identify engineerable hotspots and assess capsid robustness to structural modifications.

PADAPT 1.0 - the Pannonian Database of Plant Traits

PADAPT 1.0 is a regional plant trait database covering 2745 taxa from Hungary, providing 126,337 records on 53 attributes across six categories, with plans to expand to other Pannonian species.

Determinants of trafficking, conduction, and disease within a K+ channel revealed through multiparametric deep mutational scanning

The paper uses deep mutational scanning to analyze how mutations affect Kir2.1 channel function, trafficking, and disease, revealing structural and functional determinants of pathogenicity.

Sand dropseed (Sporobolus cryptandrus) - A new pest in Eurasian sand areas?

This paper reviews the distribution, habitat characteristics, seed bank formation, and ecological impacts of Sporobolus cryptandrus in Central and Eastern Hungary, identifying it as a potential invasive species in Eurasian sand areas.

Multivariate analysis of strawberry experiments: where are we now and where can we go?

The paper uses the MGIDI index to select superior strawberry treatments based on multiple traits, finding that imported Albion transplants in burnt rice husk substrates achieve 91% desired trait values.

The biophysical basis of protein domain compatibility

The paper uses high-throughput assays and machine learning to model biophysical interactions governing protein domain compatibility in fusion proteins.

3D FIB-SEM reconstruction of microtubule-organelle interaction in whole primary mouse beta cells

The paper provides 3D reconstructions of microtubule networks in primary mouse beta cells and shows their role in insulin secretory granule positioning.

A survey of pairwise epistasis supports an outside-in hierarchy of clade-specifying and function-defining residues in PSD95 PDZ3

The paper uses deep mutational scanning to analyze epistasis in the PSD95 PDZ3 domain, revealing an outside-in hierarchy of clade-specifying and function-defining residues.

The thrombopoietin receptor agonist eltrombopag inhibits human cytomegalovirus replication via iron chelation

This paper shows eltrombopag inhibits HCMV replication via iron chelation, effective against drug-resistant strains and synergistic with ganciclovir.

Effect of Antimicrobial Stewardship with Rapid MALDI-TOF Identification and Vitek 2 Antimicrobial Susceptibility Testing on Hospitalization Outcome

This study compares hospitalization outcomes between two years, finding faster identification and susceptibility testing with MALDI-TOF/Vitek 2 and antimicrobial stewardship, leading to shorter hospital stays.

Domain Insertion Permissibility is a Measure of Engineerable Allostery in Ion Channels

The paper introduces domain insertion permissibility as a metric to identify engineerable allosteric sites in ion channels, showing light sensitivity when inserted into allosteric sites.