Author

G. Bashiri

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Approach:wet-lab / biochemical assay· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

E. M. M. Bulloch· 2 shared J. M. Johnston· 2 shared N. A. T. Ho· 2 shared S. S. Dawes· 2 shared T. Stanborough· 2 shared D. Rifat· 1 shared E. N. Baker· 1 shared E. N. M. Jirgis· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

E. M. M. Bulloch

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Author profile →

3 papers

Recent·Most cited

Allosteric inhibition of Staphylococcus aureus MenD by 1,4-dihydroxy naphthoic acid: A feedback inhibition mechanism of the menaquinone biosynthesis pathway

T. Stanborough, N. A. T. Ho, E. M. M. Bulloch, G. Bashiri, S. S. Dawes, E. W. Akazong, J. Titterington, T. M. Allison, W. Jiao, J. M. Johnston

This study shows that DHNA allosterically inhibits Sau-MenD, a key enzyme in MK biosynthesis, and demonstrates conserved feedback inhibition in Staphylococcus aureus.

bioRxiv · Jul 12, 2022Biochemistry

Mutations in fbiD(Rv2983) as a novel determinant of resistance to pretomanid and delamanid in Mycobacterium tuberculosis

D. Rifat, S.-Y. Li, T. R. Ioerger, K. Shah, J.-P. Lanoix, J. Lee, G. Bashiri, J. C. Sacchettini, E. Nuermberger

This study identifies mutations in fbiD(Rv2983) as a novel determinant of resistance to pretomanid and delamanid in Mycobacterium tuberculosis through in vitro and in vivo experiments.

bioRxiv · Sep 10, 2020Microbiology

Allosteric Regulation of Vitamin K2 Biosynthesis in a Human Pathogen

G. Bashiri, L. V. Nigon, E. N. M. Jirgis, N. A. T. Ho, T. Stanborough, S. S. Dawes, E. N. Baker, E. M. M. Bulloch, J. M. Johnston

The paper identifies feedback inhibition of Mtb-MenD by DHNA through domain II, revealing a regulatory mechanism for menaquinone biosynthesis in Mycobacterium tuberculosis.

bioRxiv · Nov 14, 2019Biochemistry