BiochemistrybioRxiv
Allosteric inhibition of Staphylococcus aureus MenD by 1,4-dihydroxy naphthoic acid: A feedback inhibition mechanism of the menaquinone biosynthesis pathway
T. Stanborough, N. A. T. Ho, E. M. M. Bulloch…·J. M. Johnston
This study shows that DHNA allosterically inhibits Sau-MenD, a key enzyme in MK biosynthesis, and demonstrates conserved feedback inhibition in Staphylococcus aureus.
DOI 10.1098/rstb.2022.0035