T. R. Ioerger

This study identifies callyaerins as antitubercular agents targeting the M. tuberculosis-specific protein Rv2113, showing efficacy against drug-resistant strains with minimal cytotoxicity.

This study identifies Mtb genes involved in antibiotic tolerance under nutrient-starved conditions through a functional genome screen, revealing potential therapeutic targets.

This study uses transposon-sequencing to analyze functional genomic diversity across 21 Mycobacterium abscessus isolates, identifying essential and non-essential genes and previously uncharacterized genetic networks.

The paper identifies phase variation in Mycobacterium tuberculosis complex as an adaptive mechanism, showing it alters gene expression and virulence.

This study uses Drosophila to identify mycobacterial virulence factors, finding conserved mechanisms between Mmar and Mtb.

This study uses molecular barcoding to analyze genetic diversity in Mtb strains, showing L2 strains have distinct growth dynamics and resist BCG vaccination.

This paper identifies site-specific nucleotide biases affecting Himar1 transposon insertion frequencies in TnSeq datasets and introduces a new method to improve the identification of conditionally essential genes.

This study maps chemical-genetic interactions in Mycobacterium tuberculosis to identify how carbon metabolism and cell wall structure affect drug efficacy, revealing environment-dependent and -independent interactions.

The paper builds MtbTnDB, a database of Mtb TnSeq screens, enabling comparison of genetic essentiality across conditions and analysis of gene function.

This study develops genetic mouse models of latent tuberculosis, revealing that adaptive immunity differentially controls relapse depending on the model used.

This study identifies mutations in fbiD(Rv2983) as a novel determinant of resistance to pretomanid and delamanid in Mycobacterium tuberculosis through in vitro and in vivo experiments.

The paper identifies cell cycle-associated gene expression patterns in Mycobacterium tuberculosis and links them to specific biological functions.

This study identifies LepA as a conserved GTPase that enhances the synthesis of mycobacterial porins, affecting drug tolerance and membrane permeability.

This study uses a novel chemical-genetics screening strategy to identify new inhibitors of Mycobacterium tuberculosis, revealing novel compound classes targeting previously unexplored bacterial targets.

This study examines genetic changes in Mycobacterium avium isolates from infected patients over time and links these changes to altered host immune responses and increased bacterial persistence.

The paper screens 500 natural products for anti-tubercular activity, identifies five active cyclic hexapeptides, and shows structural analogs lack activity.