Author

G. C. Garcia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Approach:deep learning· 2 Assay:ATAC-seq· 1 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:imaging· 1

Frequent Co-Authors

T. J. Sejnowski· 3 shared T. M. Bartol· 3 shared G. Perkins· 2 shared P. Rangamani· 2 shared S. Phan· 2 shared A. Husar· 1 shared A. Mahapatra· 1 shared A. S. Saglam· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersBiophysics

T. J. Sejnowski

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Author profile →

4 papers

Recent·Most cited

Cristae formation is a mechanical buckling event controlled by the inner membrane lipidome

K. Venkatraman, C. T. Lee, G. C. Garcia, A. Mahapatra, D. Milshteyn, G. Perkins, K.-Y. Kim, H. A. Pasolli, S. Phan, J. Lippincott-Schwartz, M. Ellisman, P. Rangamani, I. Budin

The paper shows that cardiolipin buffers mitochondrial inner membrane curvature and ATP synthase organization, with a mathematical model predicting snapthrough instability in cristae formation.

bioRxiv · Mar 13, 2023 · PreprintBiophysics

Mitochondria morphology governs ATP production rate

G. C. Garcia, K. Gupta, T. M. Bartol, T. J. Sejnowski, P. Rangamani

This study presents a thermodynamically consistent model of mitochondrial ATP production, showing that ATP production, not export, is the limiting step and linking cytosolic ATP rates to mitochondrial morphology.

bioRxiv · Aug 16, 2022 · PreprintCell Biology

MCell4 with BioNetGen: A Monte Carlo Simulator of Rule-Based Reaction-Diffusion Systems with Python Interface

A. Husar, M. Ordyan, G. C. Garcia, J. G. Yancey, A. S. Saglam, J. Faeder, T. M. Bartol, M. B. Kennedy, T. J. Sejnowski

The paper introduces MCell4, a new version of the MCell simulation program with Python interface and BioNetGen support for rule-based reaction-diffusion modeling.

bioRxiv · May 17, 2022Biophysics

Mitochondrial morphology provides a mechanism for energy buffering at synapses

G. C. Garcia, T. M. Bartol, S. Phan, E. A. Bushong, G. Perkins, T. J. Sejnowski, M. H. Ellisman, A. Skupin

The paper presents an agent-based model of mitochondrial morphology at synapses, showing that internal structure influences energy buffering and cellular robustness.

bioRxiv · May 20, 2019Biophysics