G. Cappello

Force propagation between epithelial cells depends on active coupling and mechano-structural polarization

This study shows that force propagation between epithelial cells depends on active coupling and mechano-structural polarization, with stronger responses when polarization is perpendicular to force direction.

Light-driven biological actuators to probe the rheology of 3D microtissues

This study uses light to control cell contractility in 3D microtissues to measure their mechanical properties and anisotropy.

Extra-cellular Matrix in cell aggregates is a proxy to mechanically control cell proliferation and motility

The paper shows that global compressions of cell aggregates affect growth and cell motility through residual mechanical stress on the extracellular matrix, while selective compressions do not.

Confinement-induced transition between wave-like collective cell migration modes

This study shows that epithelial cell layers confined to narrow geometries exhibit tissue-level waves that undergo a phase transition, independent of confinement length, revealing an intrinsic mechanism for supracellular distance measurement.

Extracellular Matrix acts as pressure detector in biological tissues

The paper shows that extracellular matrix detects mechanical compression in multicellular aggregates by regulating cell behavior through deformation and dehydration.