I. Wang

Targeting PKC alleviates iron overload in diabetes and hemochromatosis

This study shows PKC inhibition reduces iron overload in diabetes and hemochromatosis by modulating ferroportin expression and trafficking.

An ERAD-independent role for rhomboid pseudoprotease Dfm1 in mediating sphingolipid homeostasis

This study identifies a novel ERAD-independent role for Dfm1 in sphingolipid homeostasis by regulating Orm2 export and degradation.

Force propagation between epithelial cells depends on active coupling and mechano-structural polarization

This study shows that force propagation between epithelial cells depends on active coupling and mechano-structural polarization, with stronger responses when polarization is perpendicular to force direction.

Cell size and actin architecture determine force generation in optogenetically activated adherent cells

This study shows that cell size and actin architecture influence force generation in optogenetically activated adherent cells through RhoA signaling dynamics.

Mechanosensitive nuclear asymmetries define a bipolar spindle scaffold to ensure mitotic fidelity

The paper shows that nuclear asymmetry during prophase, driven by mechanical cues, enables proper centrosome positioning and bipolar spindle formation for accurate mitosis.

Stick-slip dynamics of cell adhesion triggers spontaneous symmetry breaking and directional migration

Cells break symmetry through mechanical instabilities causing stochastic adhesion detachment, initiating migration without pre-established polarity.

Magneto-active substrates for local mechanical stimulation of living cells

The paper develops magneto-active substrates to apply local and dynamic mechanical stimulation to single cells, enabling study of mechanotransduction through traction and compression.