P. Moreau

An IL-1β driven neutrophil-stromal cell axis fosters a BAFF-rich microenvironment in multiple myeloma

The paper identifies a neutrophil-stromal cell feedback loop in multiple myeloma that promotes BAFF-rich inflammation, persisting after treatment and suggesting dual targeting strategies.

Force propagation between epithelial cells depends on active coupling and mechano-structural polarization

This study shows that force propagation between epithelial cells depends on active coupling and mechano-structural polarization, with stronger responses when polarization is perpendicular to force direction.

Cell size and actin architecture determine force generation in optogenetically activated adherent cells

This study shows that cell size and actin architecture influence force generation in optogenetically activated adherent cells through RhoA signaling dynamics.

LILRB1 and LILRB2 expression in peripheral blood immune cells at 18 and 24 months of age in infants born from mothers with placental malaria

This study examines LILRB1 and LILRB2 expression in immune cells of infants born to mothers with placental malaria, finding lower non-classical monocytes and higher LILRB2 expression associated with increased malaria susceptibility.

Chromatin accessibility combined with enhancer clusters activation mediates heterogeneous response to dexamethasone in myeloma cells

The paper investigates how chromatin accessibility and enhancer clusters mediate heterogeneous responses to dexamethasone in myeloma cells, showing epigenomic changes linked to transcriptional heterogeneity.

Lyso-Phosphatidic Acid Acyl-Transferases: a link with intracellular protein transport in Arabidopsis root cells?

The paper investigates the role of LPAATs in protein transport in Arabidopsis root cells, finding that their inhibition disrupts auxin transporter and aquaporin transport.

The DNA methylation landscape of multiple myeloma shows extensive inter- and intrapatient heterogeneity that fuels transcriptomic variability

This study examines DNA methylation heterogeneity in multiple myeloma, linking it to transcriptomic variability and poor patient outcomes through epigenetic and structural changes.

Sphingolipids mediate polar sorting of PIN2 through phosphoinositide consumption at the trans-Golgi Network

The paper shows that sphingolipids regulate phosphoinositide levels at the TGN by mediating PI4P consumption via PI-PLC, affecting PIN2 sorting.

DNA hydroxymethylation reveals transcription regulation networks and prognostic signatures in multiple myeloma

This study analyzes DNA hydroxymethylation in multiple myeloma to identify regulation networks and prognostic signatures associated with disease progression and survival.

In vivo phosphatidylserine variations steer Rho GTPase signaling in a cell-context dependent manner

The paper shows phosphatidylserine regulates Rho GTPase signaling in Arabidopsis by modulating ROP6 nanoclusters and auxin signaling during root development.

Genomic landscape and chronological reconstruction of driver events in multiple myeloma

This study reconstructs the genomic evolution of multiple myeloma by analyzing 67 genomes from 30 patients and public datasets, identifying 7 subgroups defined by distinct driver mutations and chronological patterns of genomic events.

Stick-slip dynamics of cell adhesion triggers spontaneous symmetry breaking and directional migration

Cells break symmetry through mechanical instabilities causing stochastic adhesion detachment, initiating migration without pre-established polarity.

A combinatorial lipid code shapes the electrostatic landscape of plant endomembranes

The paper identifies specific lipids that control membrane electrostatics in plant cells and shows how their combination creates distinct electrostatic territories along the endocytic pathway.

Magneto-active substrates for local mechanical stimulation of living cells

The paper develops magneto-active substrates to apply local and dynamic mechanical stimulation to single cells, enabling study of mechanotransduction through traction and compression.

The Odd One Out: Arabidopsis Reticulon 20 Has A Role In Lipid Biosynthesis

This study identifies Arabidopsis reticulon 20 as involved in lipid biosynthesis based on its unique ER localization and altered sterol composition in mutants.