MicrobiologybioRxiv
Growth-mediated negative feedback shapes quantitative antibiotic response
S. A. Angermayr, G. Chevereau, T. Bollenbach
This study shows that growth-mediated negative feedback shapes the shallow dose-response curve of trimethoprim in E. coli by upregulating its target gene, with implications for drug resistance evolution.
DOI 10.15252/msb.202110490