MicrobiologybioRxiv
Transcriptional adaptation of drug-tolerant Mycobacterium tuberculosis in mice
E. A. Wynn, C. Dide-Agossou, M. Reichlen…·N. D. Walter
This study develops a targeted amplification RNA sequencing method, SEARCH-TB, to analyze Mycobacterium tuberculosis transcriptomes in mice during treatment, revealing transcriptional adaptations including metabolic shifts and regulatory reprogramming.
DOI 10.1128/mbio.02363-23