NFAT5-dependent transcriptional stress control of endothelial cells prevents maladaptive remodeling of pulmonary arterioles in the hypoxic lung
H. Laban, S. Siegmund, K. Schlereth, L. Brandenburg, F. A. Trogisch, A. Weigert, C. De La Torre, A. Abukiwan, C. Mogler, M. Hecker, W. M. Kuebler, T. Korff
This study shows that NFAT5 in endothelial cells limits hypoxia-induced maladaptive remodeling of pulmonary arterioles by restricting HIF1-mediated Pdgfb expression.
bioRxiv · Oct 18, 2023Physiology