D. John

Age-dependent RGS5 loss in pericytes induces cardiac dysfunction and fibrosis in the heart

This study shows that loss of RGS5 in pericytes with age leads to cardiac dysfunction and fibrosis by altering pericyte function and activating fibroblasts.

DNMT3A clonal hematopoiesis-driver mutations induce cardiac fibrosis by paracrine activation of fibroblasts

This study shows that DNMT3A mutations in hematopoietic cells drive cardiac fibrosis by activating fibroblasts through paracrine signaling, contributing to heart failure progression.

A novel role for cystathionine gamma lyase in the control of p53: impact on endothelial senescence and metabolic reprograming

This paper identifies CSE-p53 interaction as a regulator of endothelial cell senescence and metabolic reprogramming in aging, showing that restoring this interaction can prevent senescence and promote vascular repair.

Ageing impairs the neuro-vascular interface in the heart

This study shows aging reduces nerve density in the left ventricle and dysregulates neuro-regulatory genes, leading to reduced heart rate variability.

Effects of Post-Myocardial Infarction Heart Failure on the Bone Vascular Niche

This study investigates how post-myocardial infarction heart failure affects the bone vascular niche, showing age-independent loss of type H endothelium and increased inflammatory gene expression in human bone marrow endothelium.