Discovery of New Broad-Spectrum Anti-Infectives for Eukaryotic Pathogens Using Bioorganometallic Chemistry
Y. Lin, H. Jung, C. A. Bulman, J. Ng, R. Vinck, C. O'Beirne, M. S. Moser, N. Tricoche, R. Peguero, R. W. Li, J. F. Urban, P. Le Pape, F. Pagniez, M. Moretto, T. Weil, , G. Gasser
Simple derivatives of the well-known antifungal drug fluconazole were found to be highly effective in vivo against fungal infections and potent against parasitic nematodes causing lymphatic filariasis and soil-transmitted helminths.
bioRxiv · Jun 28, 2023Pharmacology & Toxicology