Y. Lin

Marker-specific pixel attribution for single-cell protein quantification with PixAQ

PixAQ improves single-cell protein quantification in imaging mass cytometry by assigning pixel signals to specific markers using spatial and intensity models.

Combination of mitomycin C and low-dose metronidazole synergistically against Clostridioides difficile infection and recurrence prevention

This study shows that combining mitomycin C with low-dose metronidazole synergistically inhibits Clostridioides difficile growth in vitro and reduces recurrence in a mouse model.

Golgi-associated retrograde protein (GARP) complex recruits retromer to trans-Golgi network for FgKex2 and FgSnc1 recycling, necessary for development and pathogenicity of Fusarium graminearum

This study identifies the GARP complex as a mediator that recruits retromer to the trans-Golgi network, facilitating the recycling of FgKex2 and FgSnc1, which is essential for growth, development, and pathogenicity of Fusarium graminearum.

Synergistic Multi-Enzyme Cascades Assembled on Modular Protein Scaffolds for Efficient PET Biorecycling

This paper develops a modular protein scaffold system to assemble multiple enzymes for efficient PET biorecycling, achieving higher conversion rates than previous systems.

Metabolomics profiling reveals association of fermented herbal feed additive, growth performance and gut microbiota in piglets

This study shows that fermented Chinese medicine (FCM) improves piglet growth and health by increasing lactic acid and propionic acid levels and altering gut microbiota composition.

Targeting fatty acid synthase suppresses tumor development in NF2/CDKN2A-deficient malignant pleural mesothelioma

This study identifies FASN inhibition as a therapeutic strategy for NF2/CDKN2A-deficient MPM, showing reduced tumor growth in xenograft models.

FLASH proton reirradiation, with or without hypofractionation, mitigates chronic toxicity in the normal murine intestine, skin, and bone.

Genomic evolution reshapes cell type diversification in the amniote brain

The paper creates a single-cell atlas of amniote brains to study cell type diversification and identifies species-specific gene expression patterns and novel cell subtypes.

Deciphering the Preeclampsia-Specific Immune Microenvironment: The Role of Pro-inflammatory Macrophages

This study identifies pro-inflammatory macrophages as key regulators of the PE-specific immune microenvironment, linking them to Th17 and CD8+ T cell activation and gMDSC suppression in placental tissues.

Fast adaptive super-resolution lattice light-sheet microscopy for rapid, long-term, near-isotropic subcellular imaging

This paper introduces Meta-rLLS-VSIM, a super-resolution microscopy technique that achieves near-isotropic resolution with reduced training time and data requirements.

SwinCell: a transformer-based framework for dense 3D cellular segmentation

SwinCell is a 3D transformer-based framework that improves segmentation of dense cellular images by balancing local feature recognition and contextual understanding.

Hour-long, kilohertz sampling rate 3D single-virus tracking in live cells enabled by StayGold fluorescent protein fusions

This paper introduces StayGold fluorescent protein fusions to enable long-duration, high-speed 3D single-virus tracking in live cells.

Resting natural killer cells promote the progress of colon cancer liver metastasis by elevating tumor-derived sSCF

The paper identifies resting NK cells that promote colon cancer liver metastasis by enhancing tumor-derived sSCF through cell-to-cell interactions.

Large-pore connexin hemichannels function as molecule transporters independently of ion conduction

The paper shows that connexin hemichannels can transport molecules independently of ion conduction, challenging the conventional view of their function.

Hindlimb kinematics, kinetics, and muscle dynamics during sit-to-stand and sit-to-walk transitions in emus (Dromaius novaehollandiae)

This study analyzes the biomechanics of sit-to-stand and sit-to-walk transitions in emus, revealing high muscle activation and joint demands, and highlights potential applications in robotics and animal welfare.

CD40 Expression by B cells is Required for Optimal Immunity to Murine Pneumocystis Infection

The paper shows that B cell CD40 expression is necessary for effective immunity against Pneumocystis infection in mice.

A functional medicine and food homology composition discovery based on disease-related target and data mining against cardiac remodeling

This study identifies β-ecdysterone as a functional compound that counteracts cardiac remodeling by enhancing NRF2, revealing cross-talk between cardiac remodeling and neuromodulation.

Signaling events at TMEM doorways provide potential targets for inhibiting breast cancer dissemination

This study identifies CSF-1 signaling as a key mechanism in TMEM doorway function, showing its role in promoting vascular openings and tumor cell intravasation in breast cancer.

TaNF-Y-PRC2 orchestrates temporal control of starch and protein synthesis in wheat

This study identifies the TaNF-Y-PRC2 complex as a regulator of starch and protein synthesis in wheat endosperm, revealing its role in epigenetic control through histone modification and gene repression.

Parallel Molecular Data Storage by Printing Epigenetic Bits on DNA

This paper introduces a DNA-based data storage method using epigenetic modifications, achieving scalable and parallel data writing and retrieval.

Unraveling the Phenotypic States of Human innate-like T Cells: Comparative Insights with Conventional T Cells and Mouse Models

This study compares human innate-like T cells (Tinn) with conventional T cells and mouse models, revealing distinct transcriptional programs and developmental pathways.

Epithelial organoid supports resident memory CD8 T cell differentiation

This paper develops a murine vaginal epithelial organoid system that supports CD8 T cell differentiation into resident memory T cells in vitro, showing phenotypic and transcriptional similarity to in vivo TRM.

WTAP, transcriptionally regulated by p65, promotes inflammation through m6A modification and phase separation

This study identifies WTAP as a p65-regulated m6A writer that promotes inflammation via phase separation and m6A modification, offering a therapeutic target for hyperinflammation.

Multiscale mechanisms driving tissue rupture by invading cells

This study identifies a mechanism where invading cells and tissue barriers coordinate to rupture barriers through intercellular adhesions and subcellular contractility, challenging existing models of collective invasion.

Variability in the phytoplankton response to upwelling across an iron limitation mosaic within the California Current System

The paper examines how diatoms respond to upwelling in the California Current System under varying iron limitation conditions, finding that Fe-limited diatoms show reduced nutrient uptake and distinct gene expression patterns.

Ras-mediated homeostatic control of front-back signaling dictates cell polarity

This study uses optogenetics to show that RasGAPs regulate cell polarity by enhancing actomyosin contractility at the back and F-actin polymerization at the front.

Correlative single-cell hard X-ray tomography and X-ray fluorescence imaging

This paper develops a method to combine single-cell X-ray tomography and fluorescence imaging to study cellular structures and chemical element distributions.

A binding site for phosphoinositides described by multiscale simulations explains their modulation of voltage gated sodium channels

This paper uses multiscale simulations to show that PI(4,5)P2 binds to Nav channels, modulating their activity by affecting conformational changes and recovery from inactivation.

Discovery of New Broad-Spectrum Anti-Infectives for Eukaryotic Pathogens Using Bioorganometallic Chemistry

Simple derivatives of the well-known antifungal drug fluconazole were found to be highly effective in vivo against fungal infections and potent against parasitic nematodes causing lymphatic filariasis and soil-transmitted helminths.

SoyDNGP: A Web-Accessible Deep Learning Framework for Genomic Prediction in Soybean Breeding

SoyDNGP is a deep learning framework for genomic prediction in soybean breeding that outperforms existing methods in accuracy and efficiency, with a web interface for trait prediction and lookup.