H. Jung

KMT2d regulates tooth enamel development

This study investigates the role of KMT2D in amelogenesis using a conditional knockout mouse model, revealing its critical role in enamel development and identifying direct target genes involved in ameloblast differentiation.

Enhanced Omicron subvariant cross-neutralization efficacy of a monovalent SARS-CoV-2 BA.4/5 mRNA vaccine encoding a noncleaved, nonfusogenic spike antigen

This study develops a modified SARS-CoV-2 spike antigen that enhances cross-neutralization against Omicron subvariants, despite reduced neutralizing potency.

Discovery of New Broad-Spectrum Anti-Infectives for Eukaryotic Pathogens Using Bioorganometallic Chemistry

Simple derivatives of the well-known antifungal drug fluconazole were found to be highly effective in vivo against fungal infections and potent against parasitic nematodes causing lymphatic filariasis and soil-transmitted helminths.

A multi-omic Nicotiana benthamiana resource for fundamental research and biotechnology

The paper provides high-quality genome assemblies and multi-omic datasets for Nicotiana benthamiana strains LAB and QLD, along with SNP mapping, to enhance their use in research and biotechnology.

Tracing the substrate translocation mechanism in P-glycoprotein

This study reveals the substrate translocation mechanism in P-glycoprotein by determining cryoEM structures and using molecular dynamics simulations to identify conformational changes in TM1 that regulate transport.

Clonal diversification and histogenesis of malignant germ cell tumours

This study analyzes the genome and transcriptome of 547 GCT histological units to explore clonal diversification and histogenesis, finding unifying genomic and transcriptional features across GCTs.

Binding of SARS-CoV-2 fusion peptide to host membranes

This study uses molecular dynamics simulations to show that the SARS-CoV-2 fusion peptide binds rapidly to host membranes via two amphipathic helices and can withstand mechanical forces up to 250 pN, facilitated by a conserved disulfide bridge.

Hydration-induced structural transitions in biomimetic tandem repeat proteins

This study links the structural and dynamic properties of a bioinspired tandem repeat protein to its macroscopic properties using NMR spectroscopy.

Dielectrophoretic separation of randomly shaped protein particles

This paper introduces a dielectrophoretic separation technique to isolate spherical protein particles from a mixture of randomly shaped particles, increasing their purity and reducing polydispersity.

Deep Metric Learning Network using Proxies for Chromosome Classification and Retrieval in Karyotyping Test

This paper introduces Proxy-ResNeXt-CBAM, a metric learning network for chromosome classification and retrieval in karyotyping, achieving high accuracy and effective clustering of embeddings.

Mathematical investigation of microbial quorum sensing under various flow conditions

The paper mathematically models microbial quorum sensing under various flow conditions, showing how advection affects signaling molecule distribution and QS induction.

Noda-like RNA viruses infecting Caenorhabditis nematodes: sympatry, diversity and reassortment

The paper identifies a new RNA virus infecting Caenorhabditis nematodes, describes co-infections and reassortment patterns, and shows host-virus genotype interactions affecting competition.

Mechanism of electroneutral sodium/proton antiporter from transition-path shooting

This study uses transition-path shooting to simulate the Na+/H+ antiporter PaNhaP, revealing its transport mechanism and identifying key conformational changes.

ULTRAFAST LASER-PROBING SPECTROCOPY FOR STUDYING MOLECULAR STRUCTURE OF POLYMERIC PROTEINS

This paper develops a laser-probing spectroscopy technique to quantify polymeric protein crystallinity in real time.