BiochemistrybioRxivPreprint
MLKL D144K mutation activates the necroptotic activity of the N-terminal MLKL domain
K. Hrovat-Schaale, M. Kalic-Prolinsek, S. Hadzi…·G. Guncar
The paper shows that the D144K mutation in MLKL removes helix H6, activating necroptotic activity by enabling oligomerization and membrane translocation.
DOI 10.1101/2021.07.08.451689