Cancer BiologybioRxiv
Mannose metabolism inhibition sensitizes acute myeloid leukemia cells to cytarabine and FLT3 inhibitor therapy by modulating fatty acid metabolism to drive ferroptotic cell death.
K. Woodley, L. S. Dillingh, G. Giotopoulos…·P. Gallipoli
This study shows that inhibiting mannose metabolism sensitizes AML cells to cytarabine and FLT3 inhibitors by promoting ferroptotic cell death through fatty acid metabolism changes.
DOI 10.1038/s41467-023-37652-0