C. Philippe

SCD inhibition eradicates AML displaying high de novo fatty acid desaturation and synergizes with chemotherapy

SCD inhibition induces AML cell death and synergizes with chemotherapy to prolong survival in murine AML models.

STAT3 restricts prostate cancer metastasis and antiandrogen resistance by controlling LKB1/CREB signaling pathway

This study identifies STAT3's role in restricting prostate cancer metastasis and antiandrogen resistance by regulating the LKB1/CREB signaling pathway in mouse models and human patients.

HNRNPA2B1 controls an unfolded protein response-related prognostic gene signature in prostate cancer

This study identifies HNRNPA2B1 as a driver of an unfolded protein response-related gene signature linked to poor prognosis in prostate cancer.

Mannose metabolism inhibition sensitizes acute myeloid leukemia cells to cytarabine and FLT3 inhibitor therapy by modulating fatty acid metabolism to drive ferroptotic cell death.

This study shows that inhibiting mannose metabolism sensitizes AML cells to cytarabine and FLT3 inhibitors by promoting ferroptotic cell death through fatty acid metabolism changes.

What are the reference strains of Acinetobacter baumannii referring to?

This study compares modern clinical isolates and reference strains of Acinetobacter baumannii, revealing significant genetic and phenotypic differences that challenge the use of traditional reference strains.

Cancer/Testis genes are predictive of breast tumor subtypes

The paper identifies HORMAD1 and CT83 as Cancer/Testis genes predictive of basal-like breast tumors and shows their epigenetic regulation and prognostic significance.

Transcriptional regulation of HSCs in Aging and MDS reveals DDIT3 as a Potential Driver of Dyserythropoiesis

This study identifies DDIT3 as a driver of dyserythropoiesis in MDS by showing its upregulation in HSCs and its ability to disrupt erythropoiesis when overexpressed.

Antimicrobial activity of a repurposed harmine-derived compound on extensively drug-resistant Acinetobacter baumannii clinical isolates

The paper identifies a harmine-derived compound, HDC1, that inhibits growth of all tested extensively drug-resistant Acinetobacter baumannii isolates.

Microbiota and stress: a loop that impacts memory

This study shows that chronic stress alters gut microbiota in quails, and transferring this microbiota to germ-free hosts impairs memory and increases anxiety-like behavior.

Tolerogenic Dendritic Cells Shape a Transmissible Gut Microbiota that Protects from Metabolic Diseases

This study shows that tolerogenic dendritic cells promote a gut microbiota that prevents metabolic diseases by enhancing butyrate production and reducing inflammation.