Erythroid overproduction of erythroferrone causes iron overload and developmental abnormalities in mice
R. Coffey, G. Jung, J. D. Olivera, G. Karin, R. C. Pereira, E. Nemeth, T. Ganz
This study shows that excessive erythroferrone production in mice leads to iron overload and developmental issues by suppressing hepcidin and disrupting BMP signaling.
bioRxiv · Jan 9, 2021Physiology