Author

R. Coffey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Cancer Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

A. Di Ruscio· 1 shared A. K. Ebralidze· 1 shared A. R. Thurm· 1 shared B. Q. Trinh· 1 shared C. Gurnari· 1 shared C.-S. Wu· 1 shared D. E. Tenen· 1 shared D. G. Tenen· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperCancer Biology

A. Di Ruscio

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Modeling the effect of cooperativity in ternary complex formation and targeted protein degradation mediated by heterobifunctional degraders

D. Park, J. A. Izaguirre, R. Coffey, H. Xu

This paper develops a pharmacodynamic model to study how cooperativity affects ternary complex formation and protein degradation mediated by heterobifunctional degraders.

bioRxiv · Mar 22, 2022Biochemistry

Erythroid overproduction of erythroferrone causes iron overload and developmental abnormalities in mice

R. Coffey, G. Jung, J. D. Olivera, G. Karin, R. C. Pereira, E. Nemeth, T. Ganz

This study shows that excessive erythroferrone production in mice leads to iron overload and developmental issues by suppressing hepcidin and disrupting BMP signaling.

bioRxiv · Jan 9, 2021Physiology

Myeloid lncRNA LOUP Mediates Opposing Regulatory Effects of RUNX1 and RUNX1-ETO in t(8;21) AML

B. Q. Trinh, S. Ummarino, A. K. Ebralidze, E. van der Kouwe, M. A. Bassal, T. M. Nguyen, R. Coffey, D. E. Tenen, E. Fabiani, C. Gurnari, C.-S. Wu, V. E. Angarica, Y. Zhang, L. Ying, H. Yang, , D. G. Tenen

The paper identifies the long noncoding RNA LOUP as a mediator of RUNX1 and RUNX1-ETO effects in t(8;21) AML, showing it promotes myeloid differentiation and inhibits cell growth by regulating PU.1 expression.

bioRxiv · Jul 24, 2020Cancer Biology