Author

G. Kortman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

C. F. Calkhoven· 3 shared C. Müller· 2 shared H. R. Zuidhof· 2 shared M. A. Zaini· 2 shared T. Ackermann· 2 shared A. de Bruin· 1 shared D. S. Verbeek· 1 shared E. Stepanova· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersCancer Biology

C. F. Calkhoven

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3 papers

Recent·Most cited

Oncogenic functions of the m6A demethylase FTO in breast cancer cells involving translational upregulation of C/EBPβ-LIP

H. R. Zuidhof, C. Müller, G. Kortman, R. Wardenaar, E. Stepanova, F. Loayza-Puch, C. F. Calkhoven

This study shows FTO promotes oncogenic functions in TNBC by regulating C/EBPβ-LIP translation, which drives EMT and metastasis.

bioRxiv · Sep 21, 2023 · PreprintCancer Biology

C/EBPβ-LIP dually activates glycolysis and the malate aspartate shuttle to maintain NADH/NAD+ homeostasis

T. Ackermann, H. R. Zuidhof, G. Kortman, M. G. S. Rutten, M. J. C. Broekhuis, M. A. Zaini, G. Hartleben, C. F. Calkhoven

This study shows that C/EBPβ-LIP activates both glycolysis and the malate-aspartate shuttle to maintain NADH/NAD+ homeostasis, and inhibiting both could be a strategy for cancer treatment.

bioRxiv · Oct 9, 2020 · PreprintCancer Biology

Reduced expression of C/EBPβ-LIP extends health- and lifespan in mice

C. Müller, L. M. Zidek, T. Ackermann, T. de Jong, P. Liu, V. Kliche, M. A. Zaini, G. Kortman, L. Harkema, D. S. Verbeek, J. P. Tuckermann, J. von Maltzahn, A. de Bruin, Z.-Q. Wang, V. Guryev, C. F. Calkhoven

This study shows that reducing C/EBPβ-LIP expression in mice delays age-related phenotypes and extends lifespan, suggesting therapeutic potential for age-related diseases.

bioRxiv · Jan 18, 2018Cell Biology