Characterization of an amyloidogenic intermediate of transthyretin by NMR relaxation dispersion
B. I. Leach, J. A. Ferguson, G. J. Morgan, X. Sun, G. Kroon, D. Oyen, J. Dyson, P. Wright
This study uses NMR relaxation dispersion to characterize the structural dynamics of an amyloidogenic intermediate of transthyretin, revealing conformational fluctuations that promote amyloid formation.
bioRxiv · Feb 16, 2024Biophysics