Mispacking of the F87 sidechain drives aggregation-promoting conformational fluctuations in the subunit interfaces of the transthyretin tetramer
X. Sun, J. A. Ferguson, K. Yang, R. L. Stanfield, J. Dyson, P. Wright
This paper investigates how mispacking of the F87 sidechain in transthyretin tetramers affects conformational dynamics and aggregation propensity through structural and biophysical analyses.
bioRxiv · Feb 26, 2024Biophysics