Author

B. I. Leach

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

B. J. Diaz· 1 shared C. R. Vakoc· 1 shared E. M. Schatoff· 1 shared H. J. Dyson· 1 shared J. A. Ferguson· 1 shared L. Dow· 1 shared M. Foronda· 1 shared M. Shusterman· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

B. J. Diaz

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2 papers

Recent·Most cited

BiophysicsbioRxivJun 21, 2023

Probing the dissociation pathway of a kinetically labile transthyretin mutant

X. Sun, J. A. Ferguson, B. I. Leach…·P. E. Wright

This study investigates the dissociation pathway of a kinetically labile transthyretin mutant using NMR and MD simulations to quantify the energy landscape at neutral pH.

DOI 10.1021/jacs.3c10083

experimental assay

𝕏 PostBluesky

Cancer BiologybioRxivJun 21, 2019

Tankyrase inhibition sensitizes cells to CDK4 blockade

M. Foronda, Y. Tarumoto, E. M. Schatoff…·L. Dow

This study identifies that combining TNKS inhibition with CDK4 loss drives G1 cell cycle arrest and senescence in epithelial cancers.

DOI 10.1371/journal.pone.0226645

humangenetic perturbation / CRISPR

𝕏 PostBluesky