The Mitochondrial Permeability Transition Pore Activates the Mitochondrial Unfolded Protein Response and Promotes Aging
S. Angeli, A. Foulger, M. Chamoli, T. H. Peiris, A. Gerencser, A. A. Shahmirzadi, J. Andersen, G. Lithgow
This study shows that loss of OSCP in C. elegans activates the mPTP, triggers UPRmt, and shortens lifespan, while mPTP inhibition restores lifespan.
bioRxiv · Nov 3, 2020Cell Biology