Author

M. Chamoli

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Physiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:C. elegans· 4 Research Focus:cell type annotation· 3 Organism:mouse· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:development & morphogenesis· 2

Frequent Co-Authors

G. J. Lithgow· 4 shared A. C. Foulger· 3 shared M. Lucanic· 3 shared A. L. Coleman-Hulbert· 2 shared B. Onken· 2 shared C. A. Sedore· 2 shared D. Bhaumik· 2 shared D. Edgar· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersPhysiology

G. J. Lithgow

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

β-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer disease brain

S. S. Madhavan, S. Roa Diaz, S. Peralta, M. Nomura, C. D. King, A. Lin, D. Bhaumik, S. Shah, T. Blade, W. Gray, M. Chamoli, B. Eap, O. Panda, D. Diaz, T. Y. Garcia, , J. C. Newman

This study identifies β-hydroxybutyrate as a metabolic regulator of protein solubility in aging and Alzheimer's disease, showing it reduces insolubility of pathological proteins like amyloid-β.

bioRxiv · Jul 3, 2023Physiology

Antioxidants green tea extract and nordihydroguaiaretic acid confer species and strain specific lifespan and health effects in Caenorhabditis nematodes

S. A. Banse, C. A. Sedore, E. Johnson, A. L. Coleman-Hulbert, B. Onken, D. Hall, E. G. Jackson, P. Huynh, A. C. Foulger, S. Guo, T. Garrett, J. Xue, D. Inman, M. L. Morshead, W. T. Plummer, , P. C. Phillips

This study evaluates the lifespan and health effects of five compounds in Caenorhabditis nematodes, finding species- and strain-specific responses, assay-dependent outcomes, and uncoupling of lifespan and health effects.

bioRxiv · Nov 9, 2021Physiology

Aldehyde dehydrogenase 3A1 deficiency leads to mitochondrial dysfunction and impacts salivary gland stem cell self-renewal, differentiation and survival

V. Viswanathan, H. Cao, J. Saiki, D. Jiang, A. Mattingly, D. K. Nambiar, J. Bloomstein, Y. Li, S. Jiang, M. Chamoli, D. Sirjani, M. Kaplan, F. C. Holsinger, R. Liang, Z. Feng, , Q. T. Le

This study shows that ALDH3A1 deficiency causes mitochondrial dysfunction and impairs salivary gland stem cell self-renewal, differentiation, and survival.

bioRxiv · Oct 25, 2021 · PreprintCell Biology

Potassium-chelating drug sodium polystyrene sulfonate enhances lysosomal function and suppresses proteotoxicity

C. Arputhasamy, M. Lucanic, A. Rane, M. Schmidt, T. Garett, A. C. Foulger, M. Broussalian, E. Battistoni, R. B. Brem, G. J. Lithgow, M. Chamoli, J. K. Andersen

This study shows that the FDA-approved drug sodium polystyrene sulfonate enhances lysosomal function and reduces proteotoxicity in C. elegans and human neuronal cells, while also increasing lifespan.

bioRxiv · Oct 21, 2021Cell Biology

The Mitochondrial Permeability Transition Pore Activates the Mitochondrial Unfolded Protein Response and Promotes Aging

S. Angeli, A. Foulger, M. Chamoli, T. H. Peiris, A. Gerencser, A. A. Shahmirzadi, J. Andersen, G. Lithgow

This study shows that loss of OSCP in C. elegans activates the mPTP, triggers UPRmt, and shortens lifespan, while mPTP inhibition restores lifespan.

bioRxiv · Nov 3, 2020Cell Biology

Automated Lifespan Determination Across Caenorhabditis Strains and Species Reveals Assay-Specific Effects of Chemical Interventions

S. A. Banse, M. Lucanic, C. A. Sedore, A. L. Coleman-Hulbert, W. T. Plummer, E. Chen, J. L. Kish, D. Hall, B. Onken, M. P. Presley, E. G. Jones, B. W. Blue, T. Garrett, M. Abbott, J. Xue, , P. C. Phillips

The paper compares manual and automated lifespan assays in Caenorhabditis strains, finding that automated methods reproduce results but show assay-specific effects of chemical interventions.

bioRxiv · Sep 14, 2019Physiology

Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy

T. Tezil, M. Chamoli, C.-P. Ng, R. P. Simon, V. J. Butler, M. Jung, J. Andersen, A. W. Kao, E. Verdin

This study identifies p300 as a target of NDGA, showing it inhibits p300 acetyltransferase activity and activates autophagy, contributing to lifespan extension.

bioRxiv · Jul 30, 2019Cell Biology